Development of Retinal Transplants

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Development of retinal transplants.

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Adult rabbit retinal transplants.

PURPOSE To study the survival of adult retinal grafts prepared in a physiologically optimized way. METHODS Twenty-three rabbits received an adult full-thickness rabbit retinal transplant positioned under the host retina, using a vitrectomy technique. The transplants were prepared using a procedure based on a previously described in vitro model used for physiological experiments on the adult r...

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Intraocular retinal transplants.

Embryonic rat retinae transplanted into the anterior chamber of adult rat eyes of the same or different strain survive and grow. Light and electron microscopic studies show that the transplants undergo histogenetic differentiation, resulting in the development of mature inner and outer layer neurons and Müller glial cells. Vascular connections develop between the host iris and the retinal trans...

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Antigenicity and immunogenicity of allogeneic retinal transplants.

The transplantation of neuronal cells and tissues represents a promising approach for the treatment of incurable neurodegenerative diseases. Indeed, it has been reported recently that retinal transplantation can rescue photoreceptor cells and delay age-related changes in various retinal layers in rodents. However, retinal grafts deteriorate progressively after placement in recipients' eyes. Her...

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Retinal pigment epithelial transplants and retinal function in RCS rats.

PURPOSE To determine if retinal pigment epithelium (RPE) transplantation maintains visual function in Royal College of Surgeons (RCS) strain of rats. METHODS Twelve RCS rats received RPE transplants at 16 to 20 days after birth. The retinas were studied electrophysiologically and histologically from 3 to 10 months after transplantation and compared with 11 RCS controls and 11 normal rats of c...

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ژورنال

عنوان ژورنال: Acta Ophthalmologica Scandinavica

سال: 1998

ISSN: 1395-3907

DOI: 10.1034/j.1600-0420.1998.760229.x